One of the most common uses of the Queries feature is for decoupling the data from the spreadsheet. You can easily decouple the data from your workbook to reduce its size and increase calculation performance using queries.
You can copy large data sets into a separate CSV file and import into SpreadsheetWEB. Then, remove that data from your workbook, and remove any references that might cause issues (i.e. lookups). Finally, use queries to target the imported data, and bind it into a named range that can be used in your workbook calculations.